A Clinical Genetic Study of Adult Obsessive Compulsive Disorder from India

OBJECTIVE The current study aims to replicate western reports of a familial excess of syndromal and sub-syndromal Obsessive Compulsive Disorder (OCD) in OCD probands in an Indian population. METHOD 148 relatives of OCD probands were compared with 151 normal subjects, based on evaluation on Schedule for Clinical Assessment for Neuropsychiatry (SCAN). RESULTS There were no clinically significant differences in the prevalence of psychiatric disorders between the two samples. CONCLUSION In an Indian setting, the absence of familial loading in adult OCD is being reported. Whether subgroups of OCD are familial, or other factors play a role in the pathogenesis of OCD in India needs to be explored.